HighStrung follows Alex, a young guitarist with stage fright, as he arrives for an audition that could change his life. Nervous but determined, he discovers his guitar emits a mysterious glow and an eerie thrumming sound. During his audition, one of the judges and the leader of the band, Blake, quickly loses interest, leaving Alex discouraged. However, after the rejection, he plays a song to himself in the waiting room, unaware of how his guitar’s glow intensified around him, drawing the attention of both Blake and Cassidy, who is the band's drummer and the second judge. As they realize their instruments share the same supernatural energy, Blake, now impressed, offers Alex a spot in the band, as they realize each other's creative potential.