Under My Skin is inspired by real people and events, and it accurately depicts the realities, triumphs, and struggles of people living with HIV, while navigating an important conversation about acceptance and tolerance. The show introduces us to a number of characters – Jonathan, Greg, Syd, and Mario whose relationships are tested when Jonathan gets infected; Dino, an HIV-positive teen whose status is discovered through a contraction of tuberculosis; Mary Rose, a mother who unknowingly passed down the virus to her son after getting it from her husband; a gay beauty parlor employee experiencing work-related discrimination, and more. Their stories of love, pain, and acceptance are revealed through Dr. Gemma Almonte, who is studying the spread of the devastating virus.